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Case Reports
. 2011;134(2):88-95.
doi: 10.1159/000326804. Epub 2011 May 5.

Molecular cytogenetic analysis of a gliosarcoma with osseous metaplasia

H S S Dahlback  1 , L Gorunova, F Micci, D Scheie, P Brandal, T R Meling, S Heim
Affiliations
Case Reports

Molecular cytogenetic analysis of a gliosarcoma with osseous metaplasia

H S S Dahlback et al. Cytogenet Genome Res. 2011.

Abstract

Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7, -10, -13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13∼21;q21∼22).

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