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. 2011 Mar;100(3):280-1.
doi: 10.1097/HP.0b013e3182082f12.

Radiation-induced genomic instability

W F Morgan

Radiation-induced genomic instability

W F Morgan. Health Phys. 2011 Mar.

Abstract

Radiation induced genomic instability can be observed in the progeny of irradiated cells multiple generations after irradiation of parental cells. The phenotype is well established both in vivo (Morgan 2003) and in vitro (Morgan 2003), and may be critical in radiation carcinogenesis (Little 2000, Huang et al. 2003). Instability can be induced by both the deposition of energy in irradiated cells as well as by signals transmitted by irradiated (targeted) cells to non-irradiated (non-targeted) cells (Kadhim et al. 1992, Lorimore et al. 1998). Thus both targeted and non-targeted cells can pass on the legacy of radiation to their progeny. However the radiation induced events and cellular processes that respond to both targeted and non-targeted radiation effects that lead to the unstable phenotype remain elusive.

Keywords: Low dose; chromosome; genomic instability.

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