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Comparative Study
. 2011 Jun;12(2):620-6.
doi: 10.1208/s12249-011-9616-z. Epub 2011 May 10.

Achieving antral grinding forces in biorelevant in vitro models: comparing the USP dissolution apparatus II and the dynamic gastric model with human in vivo data

Maria Vardakou  1 , Annalisa Mercuri, Susan A Barker, Duncan Q M Craig, Richard M Faulks, Martin S J Wickham
Affiliations
Comparative Study

Achieving antral grinding forces in biorelevant in vitro models: comparing the USP dissolution apparatus II and the dynamic gastric model with human in vivo data

Maria Vardakou et al. AAPS PharmSciTech. 2011 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic representations of the Dynamic Gastric Model. a depicts the main components of the DGM (adapted from (19)), while b illustrates the mechanism of the mechanical digestion: (1) The meal/gastric content in the main body is inhomogeneously mixed with the gastric secretions through application of pulsatiles contractions. (2) The content is allowed to go into the antrum through the valve assembly. The inlet valve is open during the process allowing reflux and mixing between the main body and the antrum. (3) The chyme is processed mechanically by the movement of the piston and barrel, and it is forced through an annular membrane. (4) The chyme is emptied from the antrum and collected for analysis
Fig. 2
Fig. 2
Mean Breaking Time (MBT) of agar gel beads for four bead breakdown forces for both low-viscosity (LV—grey bars) and high-viscosity (HV—black bars) meals. Panel a from Marciani (24); n = 9 for the LV and n = 8 for the HV for each bead strength. Panel b in the DGM; n = 5 for each bead strength. *p < 0.05 vs. each of the two lower beads strengths for the LV meal
Fig. 3
Fig. 3
Example of the appearance of the beads at 0.78 and 0.65 N: a before processing; b after digestion in the DGM fed with LV meal; c after 2 h processing in the USP II (100 rpm) containing LV meal
Fig. 4
Fig. 4
Correlation of the in vitro MBT (DGM) and in vivo MBT for the beads at the different breaking forces. Panel a LV meal. Panel b HV meal. Straight lines are the regression lines (refer to text for fitting Eqs. 5 and 6). Bars represent SE
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