Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2011 Jun;12(2):620-6.
doi: 10.1208/s12249-011-9616-z. Epub 2011 May 10.

Achieving antral grinding forces in biorelevant in vitro models: comparing the USP dissolution apparatus II and the dynamic gastric model with human in vivo data

Maria Vardakou  1 , Annalisa Mercuri, Susan A Barker, Duncan Q M Craig, Richard M Faulks, Martin S J Wickham
Affiliations
Comparative Study

Achieving antral grinding forces in biorelevant in vitro models: comparing the USP dissolution apparatus II and the dynamic gastric model with human in vivo data

Maria Vardakou et al. AAPS PharmSciTech. 2011 Jun.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Schematic representations of the Dynamic Gastric Model. a depicts the main components of the DGM (adapted from (19)), while b illustrates the mechanism of the mechanical digestion: (1) The meal/gastric content in the main body is inhomogeneously mixed with the gastric secretions through application of pulsatiles contractions. (2) The content is allowed to go into the antrum through the valve assembly. The inlet valve is open during the process allowing reflux and mixing between the main body and the antrum. (3) The chyme is processed mechanically by the movement of the piston and barrel, and it is forced through an annular membrane. (4) The chyme is emptied from the antrum and collected for analysis
Fig. 2
Fig. 2
Mean Breaking Time (MBT) of agar gel beads for four bead breakdown forces for both low-viscosity (LV—grey bars) and high-viscosity (HV—black bars) meals. Panel a from Marciani (24); n = 9 for the LV and n = 8 for the HV for each bead strength. Panel b in the DGM; n = 5 for each bead strength. *p < 0.05 vs. each of the two lower beads strengths for the LV meal
Fig. 3
Fig. 3
Example of the appearance of the beads at 0.78 and 0.65 N: a before processing; b after digestion in the DGM fed with LV meal; c after 2 h processing in the USP II (100 rpm) containing LV meal
Fig. 4
Fig. 4
Correlation of the in vitro MBT (DGM) and in vivo MBT for the beads at the different breaking forces. Panel a LV meal. Panel b HV meal. Straight lines are the regression lines (refer to text for fitting Eqs. 5 and 6). Bars represent SE
See this image and copyright information in PMC

References

    1. Abrahamsson B, Albery T, Eriksson A, Gustafsson I, Sjöberg M. Food effects on tablet disintegration. Eur J Pharm Sci. 2004;22(2–3):165–172. doi: 10.1016/j.ejps.2004.03.004. - DOI - PubMed
    1. Lennernäs H. Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations. Mol Pharm. 2009;6(5):1429–1440. doi: 10.1021/mp9000876. - DOI - PubMed
    1. Collins PJ, Horowitz M, Cook DJ, Harding PE, Shearman DJC. Gastric emptying in normal subjects—a reproducible technique using a single scintillation camera and computer system. Gut. 1983;24:1117–1125. doi: 10.1136/gut.24.12.1117. - DOI - PMC - PubMed
    1. Davis SS, Hardy JG, Taylor MJ, Whalley DR, Wilson CG. A comparative study of the gastrointestinal transit of a pellet and tablet formulation. Int J Pharm. 1984;21(2):167–177. doi: 10.1016/0378-5173(84)90091-7. - DOI
    1. Podczeck F, Course N, Newton JM, Short MB. Gastrointestinal transit of model mini-tablet controlled release oral dosage forms in fasted human volunteers. J Pharm Pharmacol. 2007;59(7):941–945. doi: 10.1211/jpp.59.7.0005. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources