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. 2011 Jul;70(3):285-90.
doi: 10.1016/j.diagmicrobio.2011.03.010. Epub 2011 May 10.

USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?

Kristen M Kreisel  1 , O Colin Stine, J Kristie Johnson, Eli N Perencevich, Michelle D Shardell, Alan J Lesse, Fred M Gordin, Michael W Climo, Mary-Claire Roghmann
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USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?

Kristen M Kreisel et al. Diagn Microbiol Infect Dis. 2011 Jul.

Abstract

USA300 methicillin-resistant Staphylococcus aureus (MRSA) is increasing as a cause of severe community-associated bacteremic infections. We assessed severe sepsis in response to infection in patients with USA300 MRSA compared to non-USA300 MRSA bacteremia. A cohort study was conducted from 1997 to 2008 comparing sepsis in response to infection in 271 patients with MRSA bacteremia from 4 VA hospitals. Sixty-seven (25%) patients with MRSA bacteremia were USA300 MRSA; 204 (75%) were non-USA300 MRSA. The proportion of MRSA bacteremia caused by USA300 MRSA increased over time (χ² P < 0.0001). Adjusting for age and nosocomial infection, patients with USA300 MRSA bacteremia were more likely to have severe sepsis or septic shock in response to infection than patients with non-USA300 MRSA bacteremia (adjusted relative risk = 1.82; 95% confidence interval, 1.16-2.87; P = 0.01). This suggests that patients with USA300 MRSA are more likely to develop severe sepsis in response to their infection, which could be due to host or bacterial differences.

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Conflict of interest statement

No conflicts of interest exist for any of the authors.

Figures

Figure 1
Figure 1
Percent of MRSA infections complicated by bacteremia due to the USA300 MRSA strain in veterans at four VHA centers, 1997–2008. Note: MRSA: methicillin-resistant Staphylococcus aureus; VHA: Veterans Health Administration. a χ2 test for trend p<0.0001.
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