Trabedersen to target transforming growth factor-beta: when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142)
- PMID: 21558079
- PMCID: PMC3093341
- DOI: 10.1093/neuonc/nor046
Trabedersen to target transforming growth factor-beta: when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142)
Comment on
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Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study.Neuro Oncol. 2011 Jan;13(1):132-42. doi: 10.1093/neuonc/noq142. Epub 2010 Oct 27. Neuro Oncol. 2011. PMID: 20980335 Free PMC article. Clinical Trial.
References
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- Wick W, Naumann U, Weller M. Transforming growth factor-β: a molecular target for the future therapy of glioblastoma. Curr Pharm Design. 2006;12:341–349. - PubMed
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- Weller M, Fontana A. The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-β, T cell apoptosis, and the immune privilege of the brain. Brain Res Rev. 1995;21:128–151. - PubMed
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- Friese MA, Wischhusen J, Wick W, et al. RNA interference targeting TGF-β1,2 enhances NKG2D-mediated anti-glioma immune response, inhibits glioma cell migration and invasiveness and abrogates tumorigenicity in vivo. Cancer Res. 2004;64:7596–7603. - PubMed
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