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Editorial
. 2011 Jun 15;10(12):1888-9.
doi: 10.4161/cc.10.12.15620. Epub 2011 Jun 15.

Vitamin D: a new player in the world of mTOR signaling

Thomas S Lisse, Martin Hewison
Editorial

Vitamin D: a new player in the world of mTOR signaling

Thomas S Lisse et al. Cell Cycle. .
No abstract available

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Figures

Figure 1
Figure 1
Vitamin D and the inhibition of mTOR signaling. Schematic representation showing signaling via mTORC1 (black arrows) and the targets for mTOR inhibitors (red arrows), including the active form of vitamin D, 1,25(OH)2D. mTORC1 integrates responses to various cell stimuli, leading to eventual phosphorylation of eukaryotic translation-initiation factor 4E-binding protein (4EBP) and p70S6 kinase 1 (p70S6K) and to promotion of mRNA translation, ribosomal biogenesis and the suppression of autophagy. DDIT4 (DNA-damage-inducible transcript 4, also known as REDD1) facilitates the assembly and activation of the tuberous sclerosis complex (TSC)1/2 complex for eventual suppression of downstream mTOR activity through actions on ras homolog enriched in the brain (Rheb). DDIT4 mRNA and protein is upregulated by 1,25(OH)2D treatment resulting in reduced phosphorylation of S6K1 and decreased cell proliferation and growth. Other abbreviations: PIP2, phosphatidylinositol-bisphosphate 2; PIP3, phosphatidylinositol-triphosphate; PTEN, phosphatase and tensin homolog; Akt, protein kinase B; mLST8, mTOR, Raptor, LST8 homolog; PRAS40, proline-rich Akt substrate 40 kDa; DEPTOR, DEP domain-containing mTOR-interacting protein.
See this image and copyright information in PMC

References

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