Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:231789.
doi: 10.1155/2011/231789. Epub 2011 Apr 14.

Clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma

H Al-Hussaini  1 , D Hogg, M E Blackstein, B O'Sullivan, C N Catton, P W Chung, A M Griffin, D Hodgson, S Hopyan, R Kandel, P C Ferguson, J S Wunder, A A Gupta
Affiliations

Clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma

H Al-Hussaini et al. Sarcoma. 2011.

Abstract

Background. There remains controversy on the routine use of chemotherapy in localized SS. Methods. The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed. Results. Median age for AP and PP was 37.6 (range 15-76) and 14 (range 0.4-18) years, respectively. 65 (64%) patients had large tumours (>5 cm). All patients underwent en bloc surgical resection resulting in 94 (92.2%) negative and 8 (7.8%) microscopically positive surgical margins. 72 (82.8%) AP and 8 (53%) PP received radiotherapy. Chemotherapy was administered to 12 (13.8%) AP and 13 (87%) PP. 10 AP and 5 PP were evaluable for response to neoadjuvant chemotherapy, with response rate of 10% and 40%, respectively. 5-year EFS and OS was 69.3 ± 4.8% and 80.3 ± 4.3%, respectively, and was similar for AP and PP, In patients with tumors >5 cm, in whom chemotherapy might be considered most appropriate, relapse occurred in 9/19 (47%) with chemotherapy, compared to 17/46 (37%) In those without. Conclusions. Patients with localized SS have a good chance of cure with surgery and RT. Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Event-free survival of all patients who did and did not receive chemotherapy. blue line—no chemotherapy; Green line—with chemotherapy.
See this image and copyright information in PMC

References

    1. Weiss SGJ. Malignant soft tissue tumors of uncertain type. In: Weis SW, Goldblum JR, editors. Enzinger and Weiss's Soft Tissue Tumors. St. Louis, Mo, USA: C. V. Mosby; 2001. pp. 1483–1571.
    1. Ladenstein R, Treuner J, Koscielniak E, et al. Synovial sarcoma of childhood and adolescence: report of the German CWS- 81 study. Cancer. 1993;71(11):3647–3655. - PubMed
    1. Pappo AS, Fontanesi J, Luo X, et al. Synovial sarcoma in children and adolescents: the St Jude Children’s research hospital experience. Journal of Clinical Oncology. 1994;12(11):2360–2366. - PubMed
    1. Andrassy RJ, Okcu MF, Despa S, Raney RB. Synovial sarcoma in children: surgical lessons from a single institution and review of the literature. Journal of the American College of Surgeons. 2001;192(3):305–313. - PubMed
    1. Okcu MF, Munsell M, Treuner J, et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. Journal of Clinical Oncology. 2003;21(8):1602–1611. - PubMed