Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May 3;6(5):e19404.
doi: 10.1371/journal.pone.0019404.

Epidemiological features of infantile hypertrophic pyloric stenosis in Taiwanese children: a Nation-Wide Analysis of Cases during 1997-2007

Mee-Mee Leong  1 , Solomon Chih-Cheng Chen, Chih-Sung Hsieh, Yow-Yue Chin, Teck-Siang Tok, Shu-Fen Wu, Ching-Tien Peng, An-Chyi Chen
Affiliations

Epidemiological features of infantile hypertrophic pyloric stenosis in Taiwanese children: a Nation-Wide Analysis of Cases during 1997-2007

Mee-Mee Leong et al. PLoS One. .

Abstract

Objective: To describe the epidemiological characteristics of infantile hypertrophic pyloric stenosis (IHPS) in ethnic Chinese children.

Materials and methods: We reviewed the National Health Insurance claims database and analyzed data from children less than one year of age who had been diagnosed with IHPS (ICD-9-CM 750.5) and had undergone pyloromyotomy (ICD-9-CM 43.3). We analyzed the incidence, gender, age at diagnosis, length of hospital stay, seasonal variation and cost of IHPS from data collected between January 1997 and December 2007.

Results: A total of 1,077 infants met inclusion criteria, including 889 boys and 188 girls. The annual incidence of IHPS ranged from 0.30 to 0.47 per 1,000 live births with a mean incidence of 0.39 per 1,000 live births. Between 2002 and 2007, the incidence showed a declining trend (P = 0.025) with coincidentally increasing trends for both exclusive breastfeeding (P = 0.014) and breastfeeding plus bottle feeding (P = 0.004). The male-to-female rate ratio was dynamic and increased from 3.03 during the first two weeks of life to 8.94 during the 8(th) through 10th weeks of life. The overall male-to-female rate ratio was 4.30. The mean age at diagnosis was 43.1 ± 2.4 days. After analyzing the months of birth and hospital admission, no seasonal variation associated with IHPS was detected. The mean length of hospital stay was 8.28 ± 7.10 days.

Conclusions: The incidence of IHPS in Taiwan, a country with a majority ethnic Chinese population, was lower than observed incidences in Caucasian populations living in Western countries. Breastfeeding campaigns and low maternal smoking rates may contribute to the lower incidence of IHPS in Taiwan. However, additional studies with longer follow-up periods are needed.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Case number and accumulated percent of cases by weeks of life at diagnosis between 1997 and 2007 in Taiwan.
Figure 2
Figure 2. Annual incidence rate (per 1,000 live births) of pyloromyotomy among 1077 cases occurring between 1997 and 2007 in Taiwan.
See this image and copyright information in PMC

References

    1. Gibbs MK, Van Herrden JA, Lynn HB. Congenital hypertrophic pyloric stenosis. Surgical experience. Mayo Clin Proc. 1975;50:312–316. - PubMed
    1. Teele RL, Smith EH. Ultrasound in the diagnosis of idiopathic hypertrophic pyloric stenosis. N Engl J Med. 1977;296:1149–1150. - PubMed
    1. Davies RP, Linke RJ, Robinson RG, Smart JA, Hargreaves C. Sonographic diagnosis of infantile hypertrophic pyloric stenosis. J Ultrasound Med. 1992;11:603–605. - PubMed
    1. Hernanz-Schulman M. Infantile hypertrophic pyloric stenosis. Radiology. 2003;227:319–331. - PubMed
    1. Fujimoto T, Lane GJ, Segawa O, Esaki S, Miyano T. Laparoscopic extramucosal pyloromyotomy versus open pyloromyotomy for infantile hypertrophic pyloric stenosis: which is better? J Pediatr Surg. 1999;34:370–372. - PubMed