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. 2011 Jun 3;13(11):2904-7.
doi: 10.1021/ol200889s. Epub 2011 May 11.

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L

Yoshihisa Asada  1 , Aya Sukemori, Takashi Watanabe, Kuber J Malla, Takafumi Yoshikawa, Wei Li, Kazuo Koike, Chin-Ho Chen, Toshiyuki Akiyama, Keduo Qian, Kyoko Nakagawa-Goto, Susan L Morris-Natschke, Kuo-Hsiung Lee
Affiliations

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L

Yoshihisa Asada et al. Org Lett. .

Abstract

Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4-6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC(90) 0.40 nM) with the lowest cytotoxicity (IC(50) 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.

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Figures

Figure 1
Figure 1
Key HMBC and 1H-1H correlations of 6.
Figure 2
Figure 2
Key correlations in ROESY spectrum of 6.
See this image and copyright information in PMC

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