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Review
. 2011 Jul 1;12(8):1188-93.
doi: 10.2174/138945011795906561.

Rab GTPases, membrane trafficking and diseases

Guangpu Li  1
Affiliations
Review

Rab GTPases, membrane trafficking and diseases

Guangpu Li. Curr Drug Targets. .

Abstract

The Rab family of GTPases contains over 60 genes in the human genome and contributes to regulation of intracellular membrane trafficking along endocytic and exocytic pathways as well as specialized pathways in specific cell types. It has become increasingly clear that disruption of the intracellular membrane trafficking system at different stages can cause various diseases. In the past decade, altered expression levels and mutations of Rab GTPases have been associated with such diseases as cancer, Alzheimer's disease, and various genetic disorders. This review discusses the specific Rab GTPases and their involvement in the diseases.

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