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. 2011 Apr 26:1:274-6.
doi: 10.7150/thno/v01p0274.

Targeted nanoprobes reveal early time point kinetics in vivo by time-resolved MRI

Ashwinkumar Bhirde  1 , Ning Guo, Xiaoyuan Chen
Affiliations

Targeted nanoprobes reveal early time point kinetics in vivo by time-resolved MRI

Ashwinkumar Bhirde et al. Theranostics. .

Abstract

This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes.

Keywords: Commentary; Cyclic RGD Peptide; Dynamic MRI.; Integrin; Superparamagnetic Nanoparticles.

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Conflict of interest statement

Conflict of Interest: The authors have declared that no conflict of interest exists.

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