doi: 10.1016/0165-1781(90)90106-f.
Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients
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- PMID: 2156275
- DOI: 10.1016/0165-1781(90)90106-f
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Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients
Psychiatry Res.
1990 Jan.
Abstract
We compared insulin-requiring diabetic outpatients (n = 49) with normal controls (n = 42) for indices of hypothalamic-pituitary-adrenal (HPA) axis activity. Diabetic patients showed significantly elevated 9 a.m. plasma levels of cortisol as well as significantly elevated plasma levels of cortisol and adrenocorticotropic hormone (ACTH) at both 4 p.m. before and 4 p.m. after dexamethasone. Also, there was a significant correlation between postdexamethasone plasma levels of ACTH and duration of diabetes. These results suggest that HPA-axis dysregulation is found among diabetic outpatients. The possible psychiatric implications are discussed.
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