Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011;7(1):37-42.

Prognostic significance of p63, p53 and ki67 expression in laryngeal basaloid squamous cell carcinomas

C Calli  1 , A Calli, E Pinar, S Oncel, B Tatar
Affiliations
  • PMID: 21563555

Prognostic significance of p63, p53 and ki67 expression in laryngeal basaloid squamous cell carcinomas

C Calli et al. B-ENT. 2011.

Abstract

Background: It is well known that basaloid squamous call carcinoma (BSCC) is more aggressive than the usual form of squamous cell carcinoma. However, current information about the prognostic significance of basaloid squamous cell carcinoma in the larynx is sparse. We investigated p63, p53 and Ki67 in BSCC of the larynx.

Methods: In a retrospective study conducted from January 2000 to June 2006, we used immunohistochemistry to analyse the protein expression of p63, p53, and Ki-67 in paraffin-embedded tumour samples from 22 BSCC patients and compared the clinicopathological parameters with the survival outcome.

Results: Positive p63 expression was found in 16 of 22 BSCC specimens (72.7%). Expression was higher in cases without lymph node metastasis than in cases with lymph node metastasis. This investigation found an inverse correlation between the expression of p63 and lymph node status in BSCC.

Conclusion: To our knowledge, this is the first clinical study of p63 expression in laryngeal BSCC.

PubMed Disclaimer

LinkOut - more resources