Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Aug;23(4):427-34.
doi: 10.1016/j.ceb.2011.04.009. Epub 2011 May 10.

Mitochondrial division: molecular machinery and physiological functions

Yusuke Kageyama  1 , Zhongyan Zhang, Hiromi Sesaki
Affiliations
Review

Mitochondrial division: molecular machinery and physiological functions

Yusuke Kageyama et al. Curr Opin Cell Biol. 2011 Aug.

Abstract

Mitochondrial division has emerged as a key mechanism for this essential organelle to maintain its structural integrity, intracellular distribution, and functional competence. An evolutionarily conserved dynamin-related GTPase, Dnm1p/Drp1, interacts with other proteins to form the core machinery involved in mitochondrial division. We summarize recent progress in understanding how the division machinery assembles onto mitochondria and how mitochondrial division contributes to cellular physiology and human diseases.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mitochondrial shape in MEFs and Purkinje neurons. Mitochondria in wildtype and Drp1-null MEFs were visualized by immunofluorescence microscopy using antibodies against Tom20. Mitochondria in Purkinje cells were visualized by electron microscopy.
Figure 2
Figure 2
Mitochondrial division machinery in yeast and mammals.
See this image and copyright information in PMC

References

    1. Okamoto K, Shaw JM. Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes. Annu Rev Genet. 2005 - PubMed
    1. Chen H, Chan DC. Mitochondrial dynamics in mammals. Curr Top Dev Biol. 2004;59:119–144. - PubMed
    1. Jensen RE, Aiken Hobbs AE, Cerveny KL, Sesaki H. Yeast mitochondrial dynamics: fusion, division, segregation, and shape. Microscopy Research and Technique. 2000;51:573–583. - PubMed
    1. Soubannier V, McBride HM. Positioning mitochondrial plasticity within cellular signaling cascades. Biochim Biophys Acta. 2009;1793:154–170. - PubMed
    1. Cerveny KL, Tamura Y, Zhang Z, Jensen RE, Sesaki H. Regulation of mitochondrial fusion and division. Trends Cell Biol. 2007;17:563–569. - PubMed

Publication types