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. 2011 May 13;145(4):495-7.
doi: 10.1016/j.cell.2011.04.018.

Estrogen receptor transrepresses brain inflammation

David Gosselin  1 , Serge Rivest
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Estrogen receptor transrepresses brain inflammation

David Gosselin et al. Cell. .
Free article

Abstract

Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al. (2011) provide evidence that ERβ activates a transrepression pathway that suppresses inflammation and inhibits progression of pathology in a mouse model of multiple sclerosis.

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