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Editorial
. 2011 Aug;85(2):221-3.
doi: 10.1095/biolreprod.111.093146. Epub 2011 May 12.

The elusive spermatogonial stem cell marker?

Brian P Hermann, Bart T Phillips, Kyle E Orwig
Editorial

The elusive spermatogonial stem cell marker?

Brian P Hermann et al. Biol Reprod. 2011 Aug.

Abstract

Commentary on Oatley et al., “Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells.”

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Figures

FIG. 1
FIG. 1
Phenotypic and functional heterogeneity among rodent SSCs. Within the pool of Asingle spermatogonia, some express only ID4 (red nuclei), while other Asingles also express PLZF (yellow nuclei), suggesting subpopulations of Asingles and SSCs. It is not known whether some Asingles express PLZF only (green nuclei) or neither marker (not shown). It is also not known whether all or some Asingle spermatogonia (or cells beyond Asingles) make up the SSC pool. Based on results of in vitro knockdown and in vivo knockout studies that suggest that ID4 participates in SSC self-renewal, Oatley et al. propose that ID4 delineates different functional subpopulations of SSCs (i.e., quiescent and proliferating).
See this image and copyright information in PMC

Comment on

References

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