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Review
. 2011 Jul 8;286(27):23653-8.
doi: 10.1074/jbc.R110.174797. Epub 2011 May 12.

Discovering the targets of drugs via computational systems biology

Hon Nian Chua  1 , Frederick P Roth
Affiliations
Review

Discovering the targets of drugs via computational systems biology

Hon Nian Chua et al. J Biol Chem. .

Abstract

Computational systems biology is empowering the study of drug action. Studies on biological effects of chemical compounds have increased in scale and accessibility, allowing integration with other large-scale experimental data types. Here, we review computational approaches for elucidating the mechanisms of both intended and undesirable effects of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy.

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Figures

FIGURE 1.
FIGURE 1.
Chemical-genetic approaches for studying drug/target relationships. HIP, haploinsufficiency profiling; HOP, homozygous deletion profiling; HOPGI, HOP/genetic interactions analysis; MSP, multicopy suppression profiling.
See this image and copyright information in PMC

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