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. 2010 Fall;1(4):223-32.

Determinants of poor adherence to anti-tuberculosis treatment in mumbai, India

Suparna Bagchi  1 , Guirish Ambe, Nalini Sathiakumar
Affiliations

Determinants of poor adherence to anti-tuberculosis treatment in mumbai, India

Suparna Bagchi et al. Int J Prev Med. 2010 Fall.

Abstract

Objectives: In this study, we investigated the determinants of poor adherence with anti-tuberculosis therapy among pulmonary tuberculosis (TB) patients in Mumbai, India, receiving Directly Observed Treatment Short Course (DOTS) therapy.

Methods: A cross-sectional study on 538 patients receiving DOTS I and II regimen was conducted. Patients were interviewed and clinical and laboratory data were collected. Eighty seven patients were considered non-adherent. Multivariable logistic regression was used to determine risk factors associated with non-adherence.

Results: Factors associated with non-adherence were found to be different among the newly-diagnosed patients and all the other residual groups. Smoking during treatment and travel-related cost factors were significantly associated with non-adherence in the newly-diagnosed patients, while alcohol consumption and short-age of drugs were significant in the residual groups.

Conclusions: An approach, targeting easier access to drugs, an ensured drug supply, effective solutions for travel-related concerns and modification of smoking and alcohol related behaviors are essential for treatment adherence.

Keywords: Adherence; DOTS; Mumbai; Tuberculosis; drug supply; smoking.

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Conflict of interest statement

Conflict of interest statement: All authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Subject recruitment among the intensive phase (IP) and the continuous phase (CP) of DOTS I and II regimens
See this image and copyright information in PMC

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