doi: 10.1016/0014-4827(90)90102-g.
Endothelin and PDGF do not stimulate peripheral blood monocyte chemotaxis, adhesion to endothelium, and superoxide production
Affiliations
- PMID: 2156722
- DOI: 10.1016/0014-4827(90)90102-g
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Endothelin and PDGF do not stimulate peripheral blood monocyte chemotaxis, adhesion to endothelium, and superoxide production
Exp Cell Res.
1990 Apr.
Abstract
Endothelin is a potent vasoconstrictory endothelial-derived peptide which can induce smooth muscle proliferation and therefore may be proatherogenic. Platelet-derived growth factor is also a potent mitogenic vasoconstrictory protein which is proatherogenic. We report that neither endothelin nor PDGF stimulate superoxide production, or monocyte adhesion to porcine aortic endothelial cell monolayers; additionally endothelin is not a chemoattractant factor for monocytes. If endothelin and PDGF are important in atherogenesis it is unlikely that a monocyte response to these mediators is involved.
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