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. 2011 May 13:9:33.
doi: 10.1186/1477-7525-9-33.

Heath-related quality of life in thyroid cancer patients following radioiodine ablation

David Taïeb  1 , Karine Baumstarck-Barrau, Frédéric Sebag, Cécile Fortanier, Catherine De Micco, Anderson Loundou, Pascal Auquier, Fausto F Palazzo, Jean-françois Henry, Olivier Mundler
Affiliations

Heath-related quality of life in thyroid cancer patients following radioiodine ablation

David Taïeb et al. Health Qual Life Outcomes. .

Abstract

Background: There is limited information about the medium to long-term health-related quality of life (QOL) in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the determinants of medium-term QOL after the initial therapy.

Methods: Following a total thyroidectomy, 88 thyroid cancer patients received either rhTSH or hypothyroid-assisted radioiodine ablation (RRA) using 3.7 GBq (100 mCi) of radioiodine. QOL evaluation of the patients using the validated Functional Assessment of Chronic Illness & Therapy (FACIT) was performed at the time of inclusion (t0) and later at the 9-month post-RRA (t1).

Results: 83 patients were eligible for the final evaluation. Medium-term FACIT scores were not statistically different between t0 and t1 patients. All but one domain of the QOL score was similar between t0 and t1. Using a multivariate analysis, only age and immediate postoperative QOL scores were found to be determinants of the overall medium term 9-month QOL scores. Analysis showed that 'high QOL levels' (baseline and 9-month) and 'no depression', 'low anxiety levels', were associated with '<45 yrs', 'men', 'partner', and 'rhTSH stimulation'.

Conclusions: The use of radioiodine ablation does not seem to affect the medium term QOL scores of patients. Medium-term QOL is mainly determined by pre-ablation QOL. The assessment of baseline QOL might be interesting to evaluate in order to adapt the treatment protocols, the preventive strategies, and medical information to patients for potentially improving their outcomes.

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Figures

Figure 1
Figure 1
Multiple correspondence analysis (MCA), plane of the first two factorial axes (factor 1 and factor 2) representing relationship with the 9-month QOL Green circles: 9-month QOL (very low/low/high/very high); Black circles: anxiety (very low/low/high/very high), depression (no/mild/moderate/severe), baseline QOL (very low/low/high/very high); Pink circles: patients' parameters; single/partner, <45y/> = 45y, men/women, hypo/rhTSH.
See this image and copyright information in PMC

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