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Review
. 2011 May;14(5):435-40.
doi: 10.3779/j.issn.1009-3419.2011.05.10.

[The EML4-ALK fusion gene in NSCLC and the clinical progress]

[Article in Chinese]
Di Wu  1 , Hong Yu
Affiliations
Review

[The EML4-ALK fusion gene in NSCLC and the clinical progress]

[Article in Chinese]
Di Wu et al. Zhongguo Fei Ai Za Zhi. 2011 May.
No abstract available

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Figures

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1
EML4-ALK融合基因结构示意图。EML4-ALK融合发生在ALK外显子20附近，在结构上能与之融合的EML4的相应的外显子的位置如箭头所示。CC：coiled-coil域；HELP：疏水的EMAP (棘皮动物微管-相关蛋白)样蛋白域；WD：WD重复区；Kinase：ALK的酪氨酸激酶域 Structure of EML4-ALK fusion gene. The corresponding positions of exons(e) of EML4 can be fused in-frame to exon 20 of ALK are indicated by arrows. CC, coiled-coil domain; HELP, hydrophobic EMAP (echinoderm microtubule-associated protein) like protein domain; WD, WD repeats; Kinase, Tyrosine kinase domain of ALK
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References

    1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277–300. doi: 10.3322/caac.20073. - DOI - PubMed
    1. Engelman JA, Zejnullahu K, Gale CM, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res. 2007;67(24):11924–11932. doi: 10.1158/0008-5472.CAN-07-1885. - DOI - PubMed
    1. Pollmann M, Parwaresch R, Adam-Klages S, et al. Human EML4, a novelmember of the EMAP family, is essential for microtubule formation. Exp Cell Res. 2006;312(17):3241–3251. doi: 10.1016/j.yexcr.2006.06.035. - DOI - PubMed
    1. Shiota M, Fujimoto J, Semba T, et al. Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3. http://www.nature.com/articles/1210346. Oncogene. 1994;9(6):1567–1574. - PubMed
    1. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small cell lung cancer. Nature. 2007;448(7153):561–566. doi: 10.1038/nature05945. - DOI - PubMed

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