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Meta-Analysis
. 2011 Aug;93(2):e76-e79.
doi: 10.1016/j.diabres.2011.04.013. Epub 2011 May 12.

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Jason L Vassy  1 , Peter Shrader  2 , Anna Jonsson  3 , Caroline S Fox  4 , Valeriya Lyssenko  3 , Bo Isomaa  5 , Leif Groop  6 , James B Meigs  7 , Paul W Franks  8
Affiliations
Meta-Analysis

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Jason L Vassy et al. Diabetes Res Clin Pract. 2011 Aug.

Abstract

Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown.

Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study).

Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005.

Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors.

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Conflict of interest statement

Conflict of Interest

The authors have a competing interest to declare. J.B.M. has a consulting agreement with Interleukin Genetics, Inc. No other potential conflicts of interest relevant to this article were reported.

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