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Randomized Controlled Trial
. 2011 May;23(3):218-23.
doi: 10.1016/j.jclinane.2010.09.006.

Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers

Michael A Frölich  1 , Alireza Arabshahi, Charles Katholi, Jeevan Prasain, Stephen Barnes
Affiliations
Randomized Controlled Trial

Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers

Michael A Frölich et al. J Clin Anesth. 2011 May.

Abstract

Study objective: To study the effect of intravenous (IV) sedation on blood pressure (BP), heart rate (HR), and respiratory rates (RR) to determine if IV sedatives differ with respect to their effect on BP, HR, and RR.

Design: Prospective, randomized, single-blinded, placebo-controlled study.

Setting: Monitored patient care room at a clinical research center.

Subjects: 60 healthy ASA physical status 1 volunteers.

Interventions: Subjects were randomized to receive, in increasing doses, one of three IV sedatives: propofol, midazolam, or dexmedetomidine; or saline control.

Measurements: Blood pressure (systolic, diastolic), HR, and RR were recorded.

Main results: A significant dose-dependent BP reduction occurred with dexmedetomidine and, to a lesser degree, with propofol; and there was good agreement of predicted versus measured drug concentrations for all sedatives. Blood pressure and HR of participants who received midazolam did not change.

Conclusions: When administered in sedative doses, dexmedetomidine and, to a lesser extent, midazolam, reduces BP in a dose-dependent fashion. Dexmedetomidine also reduces HR. Midazolam does not affect BP or HR.

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Figures

Fig. 1
Fig. 1
Systolic and diastolic blood pressures (BPs) at baseline, during sedation and recovery. The x-axis = dose of the sedative drug, ranging from very mild (level 1) to moderate sedation (level 4).
Fig. 2
Fig. 2
Agreement of predicted versus measured drug concentrations using a simple regression model (left panel) and the model adjusted by individual intercepts. Adjusted R2 =adjusted coefficient of determination, ID=internal diameter.
See this image and copyright information in PMC

References

    1. DeFrances CJ, Lucas CA, Buie VC, Golosinskiy A. 2006 National Hospital Discharge Survey. Natl Health Stat Report. 2008;(5):1–20. - PubMed
    1. Chang C, Uchiyama A, Ma L, Mashimo T, Fujino Y. A comparison of the effects on respiratory carbon dioxide response, arterial blood pressure, and heart rate of dexmedetomidine, propofol, and midazolam in sevoflurane-anesthetized rabbits. Anesth Analg. 2009;109:84–89. - PubMed
    1. Heard C, Burrows F, Johnson K, Joshi P, Houck J, Lerman J. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesth Analg. 2008;107:1832–1839. - PubMed
    1. Phan H, Nahata MC. Clinical uses of dexmedetomidine in pediatric patients. Paediatr Drugs. 2008;10:49–69. - PubMed
    1. Koroglu A, Demirbilek S, Teksan H, Sagir O, But AK, Ersoy MO. Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results. Br J Anaesth. 2005;94:821–824. - PubMed

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