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Comment
. 2011 May 17;20(5):577-8.
doi: 10.1016/j.devcel.2011.05.001.

Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism

Jan Kitajewski  1
Affiliations
Comment

Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism

Jan Kitajewski. Dev Cell. .

Abstract

Guarani et al. (2011), reporting in Nature, identify a mechanism for fine-tuning endothelial Notch signaling by SIRT1-mediated deacetylation. This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis.

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Comment on

  • Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
    Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MHH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M. Guarani V, et al. Nature. 2011 May 12;473(7346):234-8. doi: 10.1038/nature09917. Epub 2011 Apr 17. Nature. 2011. PMID: 21499261 Free PMC article.

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