The curious case of the soluble protein
- PMID: 21571216
- DOI: 10.1016/j.devcel.2011.05.003
The curious case of the soluble protein
Abstract
How neurons tackle the challenge of soluble protein delivery to the distal axon has long puzzled neuroscientists. Reporting in Neuron, Scott et al. (2011) show that this axonal transport occurs through motor-dependent formation of dynamic heterogeneous protein complexes that pause upon complex disassembly and regain motility upon reassembly.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Mechanistic logic underlying the axonal transport of cytosolic proteins.Neuron. 2011 May 12;70(3):441-54. doi: 10.1016/j.neuron.2011.03.022. Neuron. 2011. PMID: 21555071 Free PMC article.
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