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Meta-Analysis
. 2011 Dec;17(10):724-9.
doi: 10.1016/j.parkreldis.2011.04.016. Epub 2011 May 14.

Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis

Daan C Velseboer  1 , Rob J de Haan, Wouter Wieling, David S Goldstein, Rob M A de Bie
Affiliations
Meta-Analysis

Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis

Daan C Velseboer et al. Parkinsonism Relat Disord. 2011 Dec.

Abstract

Background: Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature.

Methods: From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis.

Results: We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses.

Conclusions: The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.

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Figures

Fig. 1
Fig. 1
Flowchart of the reviewing process.
Fig. 2
Fig. 2
Point prevalences of OH in PD per study and pooled prevalence rate (with their corresponding 95% Confidence Intervals).
See this image and copyright information in PMC

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