Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978;43(2):73-91.
doi: 10.1007/BF01579067.

Effects of antidepressant agents on the synthesis of brain monoamines

A Carlsson, M Lindqvist

Effects of antidepressant agents on the synthesis of brain monoamines

A Carlsson et al. J Neural Transm. 1978.

Abstract

The effect of seventeen established or possible antidepressant agents on the synthesis of 5-HT, noradrenaline and dopamine in rat brain has been investigated by measuring the accumulation of 5-hydroxytryptophan and DOPA induced by an inhibitor of the aromatic L-aminoacid decarboxylase (3-hydroxybenzylhydrazine hydrochloride, 100 mg/kg i.p.). All the established inhibitors of 5-HT, noradrenaline and dopamine uptake were found to inhibit the synthesis of the respective monoamines, presumably by influencing a receptor-mediated feedback mechanism. A close correlation appears to exist between blockade of transmitter uptake and inhibition of transmitter synthesis. The results support current ideas on the mode of action of antidepressant agents.

PubMed Disclaimer

References

    1. Eur J Pharmacol. 1975 Dec;34(2):377-80 - PubMed
    1. Psychopharmacologia. 1973 May 21;30(2):123-34 - PubMed
    1. Life Sci I. 1971 Nov 15;10(22):1267-77 - PubMed
    1. J Pharm Pharmacol. 1969 Nov;21(11):769-73 - PubMed
    1. Pharmakopsychiatr Neuropsychopharmakol. 1976 Jan;9(1):2-10 - PubMed

LinkOut - more resources