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Randomized Controlled Trial
. 2011 Oct;30(10):904-6.
doi: 10.1097/INF.0b013e318220a68b.

Bacteremia in human immunodeficiency virus-infected children in Cape Town, South Africa

David M le Roux  1 , Mark F Cotton, Stanzi M le Roux, Andrew Whitelaw, Carl J Lombard, Heather J Zar
Affiliations
Randomized Controlled Trial

Bacteremia in human immunodeficiency virus-infected children in Cape Town, South Africa

David M le Roux et al. Pediatr Infect Dis J. 2011 Oct.

Abstract

Bacteremia contributes to morbidity of HIV-infected children. In a randomized controlled trial evaluating trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis, 47 bacteremias were detected. The incidence rate of bacteremia increased in the first 3 months after starting combination antiretroviral therapy (cART), but decreased by 74% once children were established on cART for more than 3 months. Children should be prioritized for early cART.

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