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. 2011 Apr 1;186(4):966-967.
doi: 10.1080/10426507.2010.526675.

Synthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry

Brian T Chamberlain  1 , Jorge Osuna, Boris A Kashemirov, Charles E McKenna
Affiliations

Synthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry

Brian T Chamberlain et al. Phosphorus Sulfur Silicon Relat Elem. .

Abstract

A series of novel β,γ-methylene-, monofluoromethylene-, and difluoromethylene-bisphosphonophosphate alkyl monoesters was synthesized. The compounds were conveniently detected during preparative HPLC using post-column derivatization with a phosphate-specific chemosensor.

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Figures

Figure 1
Figure 1
Structures of neopentyl bisphosphonophosphate monoesters (1–3) and zinc(II)-dipicolylamine anthracene sensor (4).
See this image and copyright information in PMC

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