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. 1993 Apr 1;3(1):47-50.

The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction

Thomas E Starzl  1 , Anthony J Demetris, Massimo Trucco, Camillo Ricordi, Noriko Murase, Angus W Thomson
Affiliations

The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction

Thomas E Starzl et al. Transplant Sci. .
No abstract available

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Figures

Fig. 1
Fig. 1
Current understanding of the graft and systemic chimerism that occurs after intestinal transplantation. Note the automatic production of mixed allogenic chimerism, providing the preexisting immunologic apparatus is not iatrogenically damaged on either donor or recipient side (see text). Evolution of this concept permitted successful clinical intestinal transplantation trials.
Fig. 2
Fig. 2
Strategies to bring “underprivileged” organs like the heart and kidney to the same level of tolerogenicity advantage as the liver, by infusing bone marrow cells or other immunocytes from the whole organ donor.
See this image and copyright information in PMC

References

    1. Starzl TE, Demetris AJ, Murase N, et al. Cell migration, chimerism, and graft acceptance. Lancet. 1992;339:1579–1582. - PMC - PubMed
    1. Starzl TE, Marchioro TL, Waddell WR. The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg Gynecol Obstet. 1963;117:385–395. - PMC - PubMed
    1. Wilson WEC, Kirkpatrick CH. Immunologic aspects of renal homotransplantation. In: Starzl TE, editor. Experience in Renal Transplantation. Philadelphia: WB Saunders Company; 1964. pp. 239–261.
    1. Starzl TE, Demetris AJ, Trucco M. Chimerism and donor specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation. in press. - PMC - PubMed
    1. Kashiwagi N, Porter KA, Penn I, et al. Studies of homograft sex and of gamma globulin phenotypes after orthotopic homotransplantation of the human liver. Surg Forum. 1969;20:374–376. - PMC - PubMed

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