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. 2011 Jan;4(1):29-32.
doi: 10.4103/0974-2077.79185.

Nevus depigmentosus treated by melanocyte-keratinocyte transplantation

Sanjeev V Mulekar  1 , Ahmed Al Issa, Abdullah Al Eisa
Affiliations

Nevus depigmentosus treated by melanocyte-keratinocyte transplantation

Sanjeev V Mulekar et al. J Cutan Aesthet Surg. 2011 Jan.

Abstract

Background: Nevus depigmentosus is a congenital, nonprogressive hypopigmented disorder. Various therapeutic methods have been attempted to repigment nevus with variable results.

Objective: The objective of this study is to report our experience of treatment of nevus depigmentosus with a combination of noncultured melanocyte-keratinocyte transplantation (MKTP) and excimer laser sessions.

Materials and methods: Six patients (male 1, female 5) of nevus depigmentosus were treated with a combination of noncultured melanocyte-keratinocyte transplantation and excimer laser. One patient was lost to follow-up. Remaining five patients were observed for a period ranging from 7 to 30 months.

Results: Two patients responded poorly to MKTP. The remaining three patients responded with repigmentation ranging from 80% to 100% but the quality of repigmentation was unsatisfactory in two of them.

Conclusion: Though repigmentation of nevus depigmentosus is possible by grafting techniques, the results are inconsistent and recurrence is possible.

Keywords: Grafting; melanocyte transplantation; nevus; nevus depigmentosus; nevus treatment.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1a
Figure 1a
13-year-old African female child before treatment
Figure 2a
Figure 2a
3-year-old Saudi female child before treatment
Figure 1b
Figure 1b
3 months posttransplantation and postexcimer laser. Note good repigmentation
Figure 2b
Figure 2b
6 months posttransplantation with good repigmentation
Figure 1c
Figure 1c
7 months posttransplantation. Note partial loss of pigmentation
See this image and copyright information in PMC

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