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. 1996 Dec:129:615-636.
doi: 10.1111/j.1749-6632.1966.tb12883.x.

LIGHT AND ELECTRON MICROSCOPIC STUDY OF BIOPSIES FROM THIRTY-THREE HUMAN RENAL ALLOGRAFTS AND AN ISOGRAFT 134-212 YEARS AFTER TRANSPLANTATION

K A Porter  1 , J M Rendall, C Stolinski, P I Terasaki, T L Marchioro, T E Starzl
Affiliations

LIGHT AND ELECTRON MICROSCOPIC STUDY OF BIOPSIES FROM THIRTY-THREE HUMAN RENAL ALLOGRAFTS AND AN ISOGRAFT 134-212 YEARS AFTER TRANSPLANTATION

K A Porter et al. Ann N Y Acad Sci. 1996 Dec.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Biopsy of renal allograft one year and ten months after transplantation (LD54). PAS-positive material is deposited in the glomerular capillary walls and in the mesangium (PAS, × 340).
FIGURE 2
FIGURE 2
Biopsy of renal allograft one year and ten months after transplantation (LD41). There is a diffuse subendothelial accumulation of amorphous material (dep) on the basement membranes (bm) of two capillary loops. A few epithelial foot processes are fused (arrows), cap = capillary lumen, end = endothelial cell, ep = epithelial cell with foot processes, us = urinary space, rbc = erythrocyte. Electron micrograph. (Lead stain, × 6,320). (Compare with Fig. 5).
FIGURE 3
FIGURE 3
Biopsy of renal allograft two years and one and one-half months after transplantation (LD18). Segment of glomerular capillary wall in which the basement membrane (bm) is thickened by a subendothelial accumulation of fine granular material (dep). Endothelial cell fragments (f) are embedded in this amorphous deposit and the lamina interna rara is obliterated, cap = capillary lumen, end = endothelial cell, ep = epithelial cell with foot processes. Electron micrograph. (Lead stain, × 12,350).
FIGURE 4
FIGURE 4
Biopsy of renal allograft one year and ten months after transplantation (LD40). Part of glomerular tuft in which there are deposits on the capillary basement membranes (bm), between the endothelial cells (end) and in the mesangial matrix (mes). There is widespread fusion of epithelial foot processes (arrows). The capillary lumen (cap) is greatly narrowed by swollen endothelial cells, us = urinary space. Electron micrograph. (Lead stain, × 5,185).
FIGURE 5
FIGURE 5
Biopsy of renal isograft two years and two and one-half months after transplantation (IDT2). Part of three glomerular capillary loops. A few epithelial foot processes are fused (arrows). The capillary basement membrane (bm) is normal in this area, cap = capillary lumen, ep = epithelial cell with foot processes, us = urinary space, rbc = erythrocyte, mes = mesangium. Electron micrograph. (Lead stain, × 6,525).
FIGURE 6a
FIGURE 6a
Biopsy of renal allograft one year and nine months after transplantation (LD15). The juxta-glomerular apparatus (arrow) is enlarged and there is thickening of the glomerular capillary walls.
FIGURE 6b
FIGURE 6b
Other kidney from donor to LD15. This man was killed in an accident two years and four months after giving the kidney illustrated in 6a, to his brother. Enlargement of the juxta-glomerular apparatus is as pronounced in this hypertrophied kidney as it is in the transplant. (PAS, × 300).
FIGURE 7
FIGURE 7
Biopsy of renal allograft one year and ten months after transplantation (LD63). Homogeneous hyaline material is present in the wall of an afferent arteriole (arrow). There is also hypertrophy of the juxta-glomerular apparatus (JGA) (PAS, × 350).
FIGURE 8
FIGURE 8
Arteriole from renal allograft (LD63) shown in Fig. 7. Hyaline material (hy) is present between the endothelium (end) and the medial smooth muscle cells (sm). Adjacent to the granular hyaline deposit there is an accumulation of material having a delicate fibrillar structure (fib). The muscle cells contain dense pigment bodies (arrows). Electron micrograph. (Lead stain, × 3,200).
FIGURE 9
FIGURE 9
Biopsy of renal allograft one year and ten months after transplantation (LD12). The lumina of two small interlobular arteries are narrowed by intimal thickening. (Weigert's elastic counterstained with van Gieson. × 300).
FIGURE 10
FIGURE 10
Biopsy of renal allograft one year and eleven and one-half months after tlansplantation (LD30). Part of the wall of a small interlobular artery. There is an accumulation of partly granular and partly fibrillar material (dep) together with some smooth muscle cells (sm) between the endothelial cells (end) lining the artery and the internal elastic lamina (el), med = medial muscle. Electron micrograph (Lead stain, × 7,000).
FIGURE 11
FIGURE 11
Biopsy of renal allograft two years after transplantation (LD27). There are three lymphoid cells in the interstitium. The cytoplasm of each contains many free ribosomes. Electron micrograph. (Lead stain, × 6,000).
FIGURE 12
FIGURE 12
Biopsy of renal allograft one year 1112 months after transplantation (LD30). A plasma cell (PC) with abundant rough endoplasmic reticulum and a small lymphocyte (SL) are lying in the interstitium. Electron micrograph. (Lead stain, × 6,000).
See this image and copyright information in PMC

References

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