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. 1993 Aug;3(2):213-7.
doi: 10.3892/ijo.3.2.213.

Recovery of response to adriamycin and cyclophosphamide by lonidamine in previously treated metastatic breast-cancer patients

M Tomirotti  1 , G Bernardo, C Epifani, R Biasioli, R Franchi, F Mensi, P Carnaghi, G Schieppati, A Scanni
Affiliations

Recovery of response to adriamycin and cyclophosphamide by lonidamine in previously treated metastatic breast-cancer patients

M Tomirotti et al. Int J Oncol. 1993 Aug.

Abstract

Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 partial remissions. Disease stability and progression were observed in 8 and 13 cases, respectively. These results were obtained with a marginal toxicity in addition to that already reported for AC therapy, the main additional side effect being myalgia, which was easily manageable in most cases.

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