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. 2011 Aug 5;10(8):3429-38.
doi: 10.1021/pr200021n. Epub 2011 Jun 21.

Biospecimen reporting for improved study quality (BRISQ)

Helen M Moore  1 , Andrea B Kelly, Scott D Jewell, Lisa M McShane, Douglas P Clark, Renata Greenspan, Daniel F Hayes, Pierre Hainaut, Paula Kim, Elizabeth Mansfield, Olga Potapova, Peter Riegman, Yaffa Rubinstein, Edward Seijo, Stella Somiari, Peter Watson, Heinz-Ulrich Weier, Claire Zhu, Jim Vaught
Affiliations

Biospecimen reporting for improved study quality (BRISQ)

Helen M Moore et al. J Proteome Res. .

Abstract

Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues, it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected.

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Figures

Figure 1
Figure 1
The Lifecycle of the Biospecimen. The preanalytical phase of the lifecycle of the biospecimen includes each stage from Patient to Distribution. Preanalytical variables are addressed in the BRISQ list.
See this image and copyright information in PMC

References

    1. Srinivasan M, Sedmak D, Jewell S. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am J Pathol. 2002;161(6):1961–71. - PMC - PubMed
    1. Moore HM, Compton CC, Lim MD, et al. Biospecimen Research Network Symposium: Advancing Cancer Research through Biospecimen Science. Cancer Res. 2009;69:6770–6772. - PMC - PubMed
    1. Apweiler R, Aslanidis C, Deufel T, et al. Approaching clinical proteomics: current state and future fields of application in cellular proteomics. Cytometry A. 2009a;75(10):816–32. - PubMed
    1. Apweiler R, Aslanidis C, Deufel T, et al. Approaching clinical proteomics: current state and future fields of application in fluid proteomics. Clin Chem Lab Med. 2009b;47(6):724–44. - PubMed
    1. Espina V, Muelle C, Edmiston K, et al. Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability. Proteomics Clin Appl. 2009;3:874–82. - PMC - PubMed

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