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. 1990 Feb 26;510(1):158-60.
doi: 10.1016/0006-8993(90)90745-w.

D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes

G B Watson  1 , M A Bolanowski, M P Baganoff, C L Deppeler, T H Lanthorn
Affiliations

D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes

G B Watson et al. Brain Res. .

Abstract

In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.

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