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Comment
. 2011 May 19;9(5):351-3.
doi: 10.1016/j.chom.2011.05.001.

Innate DNA sensing moves to the nucleus

Leonie Unterholzner  1 , Andrew G Bowie
Affiliations
Free article
Comment

Innate DNA sensing moves to the nucleus

Leonie Unterholzner et al. Cell Host Microbe. .
Free article

Abstract

It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.

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