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. 2011 Jul;55(7):3579-83.
doi: 10.1128/AAC.01783-10. Epub 2011 May 16.

Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil

Leonardo Neves Andrade  1 , Tânia Curiao, Joseane Cristina Ferreira, Juliana Mucedola Longo, Eduardo Carneiro Clímaco, Roberto Martinez, Fernando Bellissimo-Rodrigues, Aníbal Basile-Filho, Marco Antônio Evaristo, Pedro F Del Peloso, Vanessa Bley Ribeiro, Afonso Luis Barth, Milena Cristina Paula, Fernando Baquero, Rafael Cantón, Ana Lúcia da Costa Darini, Teresa M Coque
Affiliations

Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil

Leonardo Neves Andrade et al. Antimicrob Agents Chemother. 2011 Jul.

Abstract

This article reports the spread of bla(KPC-2) in the Sao Paulo and Rio de Janeiro states, facilitated by globally spread K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, and ST437) and a diversity of plasmids (IncFII, IncN, and IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of the Enterobacteriaceae (Enterobacter cloacae, Serratia marcescens, and Citrobacter freundii). It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city.

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Figures

Fig. 1.
Fig. 1.
Geographic distribution of KPC-2-producing Enterobacteriaceae in Brazil. Abbreviations: ES, Espirito Santo; GO, Goias; DF, Distrito Federal; MG, Minas Gerais; PE, Pernambuco; RJ, Rio de Janeiro; RS, Rio Grande do Sul; SP, Sao Paulo; ND, not determined. States where KPC producers were isolated appear shaded in gray. K. pneumoniae isolates are represented by circles, E. cloacae isolates by squares, S. marcescens by a triangle, C. freundii by a hexagon, and E. coli isolates by a rhombus. Bold circles represent STs belonging to CC258 (ST258, ST11, and ST437). Clones analyzed in this study are indicated by arrows. ST25 and ST327 are double-locus variants of each other.
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References

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