Eosinophilic esophagitis: update on clinicopathological manifestations and pathophysiology

Abstract

Purpose of review: Over the course of the last year, a number of studies have brought new insights into the clinical presentation, pathogenesis, and treatment of eosinophilic esophagitis, some of which will be summarized here.

Recent findings: This swell of research and clinical need resulted in revision of the 2007 Consensus Recommendations. In addition, new insights into key clinicopathological features including symptoms such as feeding dysfunction and histological quantification of eosinophil extracellular granules are presented. The advancement of the field is strongly supported by blinded and placebo-controlled studies of IL-5 and oral viscous budesonide as well as new large studies examining the safety of dilation.

Summary: Overall, these studies set the stage for new methodologies to understand the pathophysiology of eosinophilic esophagitis and development of novel therapies.