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Comparative Study
. 1990 May;64(5):2110-6.
doi: 10.1128/JVI.64.5.2110-2116.1990.

Structure and function of the Epstein-Barr virus BZLF1 protein

G Packham  1 , A Economou, C M Rooney, D T Rowe, P J Farrell
Affiliations
Comparative Study

Structure and function of the Epstein-Barr virus BZLF1 protein

G Packham et al. J Virol. 1990 May.

Abstract

Five DNA-binding sites for the Epstein-Barr virus BZLF1 protein have been identified within three of the early viral promoters, and four of these binding sites contain a consensus AP-1 site. The part of the BZLF1 protein required for sequence-specific DNA binding to one of these AP-1-like sites was identified by deletion mapping. Site-directed mutagenesis of this DNA target suggests that BZLF1 may work partly by overcoming a cellular repressor of viral transcription.

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References

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