1-[3,5-Bis(trifluoro-meth-yl)phen-yl]-3-[(5-ethenyl-1-aza-bicyclo-[2.2.2]octan-2-yl)(6-methoxy-quinolin-4-yl)meth-yl]thio-urea-l-proline-methanol (1/1/1)

Abstract

In the methanol solvate of the title 1:1 cocrystal, C(29)H(28)F(6)N(4)OS·C(5)H(9)NO(2)·CH(4)O, the l-proline mol-ecule exists as a zwitterion. In the crystal, the disubstituted thio-urea, l-proline and methanol mol-ecules are linked by N-H⋯O and N-H⋯N hydrogen bonds, forming a two-dimensional array in the ab plane.

Fig. 1.

Molecular structure of the disubstituted urea molecule in (I), showing displacement ellipsoids at the 70% probability level.

Fig. 2.

Molecular structure of zwitterionic L-proline, showing displacement ellipsoids at the 70% probability level.

Fig. 3.

Supramolecular chain along the a axis in (I) mediated by N–H···O (orange dashed lines) and N–H···N hydrogen bonds (blue dashed lines).

Fig. 4.

2-D array in the ab plane in (I) mediated by N–H···O (orange dashed lines) and N–H···N hydrogen bonds (blue dashed lines).