Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;220(2):229-33.
doi: 10.1007/BF00260486.

Mitomycin C induces genomic rearrangements involving transposable elements in Drosophila melanogaster

P G Georgiev  1 , S E Korochkina, S G Georgieva, T I Gerasimova
Affiliations

Mitomycin C induces genomic rearrangements involving transposable elements in Drosophila melanogaster

P G Georgiev et al. Mol Gen Genet. 1990 Jan.

Abstract

Mitomycin C was injected into the abdomen of male flies of the y2 sc1 waG strain of Drosophila melanogaster. They were mated with females bearing attached-X chromosomes, and the male offspring (F1) were analysed for the appearance of mutations in the X chromosome. We observed y+ and sc+ reversions induced either by excision of mdg4 (gypsy) with retention of one long terminal repeat (LTR) or by insertion of a foreign sequence into mdg4, partial reversion of the waG mutation, waG----waGd, and unstable f mutations. The overall mutation frequency was considerably higher than in control flies of the y2 sc1 waG strain. Possible mechanisms of genomic rearrangements induced by Mitomycin C, in particular the role of homologous recombination, are discussed.

PubMed Disclaimer

References

    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. Genetics. 1961 Nov;46:1385-8 - PubMed
    1. Cell. 1981 Sep;25(3):693-704 - PubMed
    1. Mol Gen Genet. 1989 Aug;218(2):208-13 - PubMed
    1. Mutat Res. 1983 Jun;120(4):233-9 - PubMed

LinkOut - more resources