Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Mar 27;66(Pt 4):o952.
doi: 10.1107/S1600536810010500.

4-Hydr-oxy-3-(1'-methyl-2-oxo-4'-phenyl-spiro-[indoline-3,2'-pyrrolidine]-3'-yl-carbon-yl)quinolin-2(1H)-one

K Revathi, M Sankaran, P Ramesh, P S Mohan, M N Ponnuswamy

4-Hydr-oxy-3-(1'-methyl-2-oxo-4'-phenyl-spiro-[indoline-3,2'-pyrrolidine]-3'-yl-carbon-yl)quinolin-2(1H)-one

K Revathi et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

In the title compound, C(28)H(23)N(3)O(4), the dihedral angle between the quinoline and indole ring systems is 29.30 (5)°. The pyrrolidine ring adopts a twist conformation. An intra-molecular O-H⋯O hydrogen bond generates an S(6) ring motif. A weak intra-molecular C3-H3⋯O3 inter-action is also observed. In the crystal, mol-ecules are linked by two sets of N-H⋯O hydrogen bonds, forming centrosymmetric dimers containing two R(2) (2)(8) ring motifs. The dimers are linked via C-H⋯π inter-actions.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
The molecular structure of the title compound, showing the atomic numbering and displacement ellipsoids drawn at the 50% probability level. The dashed line indicates a hydrogen bond.
Fig. 2.
Fig. 2.
The crystal packing of the title compound. H atoms not involved in hydrogen bonding (dashed lines) have been omitted for clarity.
See this image and copyright information in PMC

References

    1. Amalraj, A., Raghunathan, R., Sridevi Kumari, M. R. & Raman, N. (2003). Bioorg. Med. Chem.11, 407–419. - PubMed
    1. Bernstein, J., Davis, R. E., Shimoni, L. & Chang, N. L. (1995). Angew. Chem. Int. Ed. Engl.34, 1555–1573.
    1. Bruker (2008). APEX2, SAINT and SADABS Bruker AXS Inc., Madison, Wisconsin, USA.
    1. Cordell, G. (1981). Introduction to Alkaloids: A Biogenic Approach. New York: Wiley International.
    1. Cremer, D. & Pople, J. A. (1975). J. Am. Chem. Soc.97, 1354–1358.