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. 2008 Oct 15;64(Pt 11):o2120.
doi: 10.1107/S1600536808033205.

(Anthracen-9-yl)(piperidin-1-yl)-methanone

Hua-You Hu, Yu-Cheng Huang, Hai-Tao Yu, Yan Zhang

(Anthracen-9-yl)(piperidin-1-yl)-methanone

Hua-You Hu et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

The title compound, C(20)H(19)NO, is a substructure of CP-640186, a potent inhibitor of mammalian acetyl-coenzyme A carboxyl-ases. In the crystal structure, the amide group forms a dihedral angle of 87.0 (1)° with the plane of the anthracene unit and the piperidine ring adopts a chair conformation. Mol-ecules are arranged into layers parallel to (100) and adjacent anthracene units within layers form dihedral angles of 13.2 (1)°. C-H⋯O inter-actions from the piperidine rings to the C=O group of the amide are observed between layers.

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Figures

Fig. 1.
Fig. 1.
The molecular structure of the title compound with displacement ellipsoids shown at 30% probability for non-H atoms.
See this image and copyright information in PMC

References

    1. Bruker (2000). SADABS, SAINT and SMART Bruker AXS Inc., Madison, Wisconsin, USA.
    1. Harwood, H. J., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., Magee, W. P., Dalvie, D. K., Soliman, V. F., Martin, W. H., Mularski, C. J. & Eisenbeis, S. A. (2003). J. Biol. Chem.278, 37099–37111. - PubMed
    1. Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. - PubMed
    1. Zhang, H.-L., Tweel, B., Li, J. & Tong, L. (2004). Structure, 12, 1683–1691. - PubMed