Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin
- PMID: 2158151
- DOI: 10.1016/0049-3848(90)90074-m
Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin
Abstract
In a double blind randomized trial on 250 patients undergoing elective abdominal surgery the effect of Fragmin was compared with heparin. Patients over 40 years of age except appendectomy and herniotomy were included. The dose of heparin was 5,000 IU b.i.d. whilst Fragmin was given in a dose of 2,500 U once per day and the second injection was a placebo. Prophylaxis started 2 h preoperatively and was maintained for 7 days. The fibrinogen uptake test was used as a screening method for thrombosis which was confirmed by phlebography. 124 patients were in the heparin group and 126 in the Fragmin group. Comparability between groups was found in: age, sex, Broca index, amount and type of risk factors, type of surgery. Thromboembolism was found in 10 cases in each group. Blood transfusions on the postoperative days 1 to 6 were required in 2 Fragmin and in 12 heparin patients. The total amount of blood given during that time was 6 units in the Fragmin and 37 units in the heparin group. These differences were significant.
Similar articles
-
Low dose heparin versus low molecular weight heparin (Kabi 2165, Fragmin) in the prophylaxis of thromboembolic complications of abdominal oncological surgery.Eur J Clin Invest. 1988 Dec;18(6):561-7. doi: 10.1111/j.1365-2362.1988.tb01268.x. Eur J Clin Invest. 1988. PMID: 2852111 Clinical Trial.
-
The thromboprophylactic effect of a low-molecular-weight heparin (Fragmin) in hip fracture surgery. A placebo-controlled study.Clin Orthop Relat Res. 1992 May;(278):95-100. Clin Orthop Relat Res. 1992. PMID: 1314147 Clinical Trial.
-
[Prevention of thromboembolism in hysterectomies with low molecular weight heparin Fragmin].Geburtshilfe Frauenheilkd. 1988 Mar;48(3):160-4. doi: 10.1055/s-2008-1035716. Geburtshilfe Frauenheilkd. 1988. PMID: 2836259 Clinical Trial. German.
-
Prophylaxis of postoperative deep vein thrombosis in general surgery: experiences with Fragmin.Acta Chir Scand Suppl. 1988;543:87-9. Acta Chir Scand Suppl. 1988. PMID: 2847463 Review. No abstract available.
-
Low molecular weight heparin for the prevention of venous thromboembolism after abdominal surgery.Br J Surg. 2004 Aug;91(8):965-74. doi: 10.1002/bjs.4639. Br J Surg. 2004. PMID: 15286956 Review.
Cited by
-
Dalteparin: an update of its pharmacological properties and clinical efficacy in the prophylaxis and treatment of thromboembolic disease.Drugs. 2000 Jul;60(1):203-37. doi: 10.2165/00003495-200060010-00010. Drugs. 2000. PMID: 10929935 Review.
-
American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients.Blood Adv. 2019 Dec 10;3(23):3898-3944. doi: 10.1182/bloodadvances.2019000975. Blood Adv. 2019. PMID: 31794602 Free PMC article.
-
Formulary management of low molecular weight heparins.Pharmacoeconomics. 2000 Jan;17(1):1-12. doi: 10.2165/00019053-200017010-00001. Pharmacoeconomics. 2000. PMID: 10747761 Review.
-
Cost effectiveness of dalteparin for preventing venous thromboembolism in abdominal surgery.Pharmacoeconomics. 2005;23(9):927-44. doi: 10.2165/00019053-200523090-00005. Pharmacoeconomics. 2005. PMID: 16153135
-
Low molecular weight heparins. An objective overview.Drugs Aging. 1992 Sep-Oct;2(5):406-22. doi: 10.2165/00002512-199202050-00005. Drugs Aging. 1992. PMID: 1327312 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical