doi: 10.1128/AAC.34.2.373.
Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro
Affiliations
- PMID: 2158278
- PMCID: PMC171593
- DOI: 10.1128/AAC.34.2.373
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Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro
Antimicrob Agents Chemother.
1990 Feb.
Abstract
Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.
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