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. 1990 Feb;34(2):373-5.
doi: 10.1128/AAC.34.2.373.

Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro

J F Manischewitz  1 , G V Quinnan Jr, H C Lane, A E Wittek
Affiliations

Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro

J F Manischewitz et al. Antimicrob Agents Chemother. 1990 Feb.

Abstract

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

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