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. 1990 May;33(5):1360-3.
doi: 10.1021/jm00167a012.

Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines

J L Kelley  1 , J A Linn, J W Selway
Affiliations

Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines

J L Kelley et al. J Med Chem. 1990 May.

Abstract

A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes.

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