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Review
. 2011 Jul;14(4):341-6.
doi: 10.1097/MCO.0b013e328347970b.

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states

David L Morris  1 , Kanakadurga Singer, Carey N Lumeng
Affiliations
Review

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states

David L Morris et al. Curr Opin Clin Nutr Metab Care. 2011 Jul.

Abstract

Purpose of review: Proinflammatory adipose tissue macrophages (ATMs) contribute to obesity-associated disease morbidity. We will provide an update of the current state of knowledge regarding the phenotypic and functional diversity of ATMs in lean and obese mice and humans.

Recent findings: The phenotypic diversity of ATMs is now known to include more than two types requiring an expansion of the simple concept of an M2 to M1 shift with obesity. Potential functions for ATMs now include the regulation of fibrosis and response to acute lipolysis in states of caloric restriction. Novel pathways that can potentiate ATM action have been identified, which include inflammasome activation and the response to lipodystrophic adipose tissue. Studies provide a new appreciation for the ability of ATMs to respond dynamically to the adipose tissue microenvironment.

Summary: ATMs play a key role in shaping the inflammatory milieu within adipose tissue, and it is now apparent that ATM heterogeneity is acutely shaped by the adipose tissue environment. To account for the new findings, we propose a new nomenclature for ATM subtypes that takes into account their diversity.

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References

    1. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867. - PubMed
    1. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219–246. - PubMed
    1. Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15:914–920. - PubMed
    1. Wentworth JM, Naselli G, Brown WA, et al. Pro-inflammatory CD11c+ CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes. 2010;59:1648–1656. This study characterizes type 1 and type 2 ATMs in lean and obese women and identifies proinflammatory CD11c+CD206+ ATMs (type 1b) in crown-like structures. - PMC - PubMed
    1. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175–184. - PMC - PubMed

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