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. 2011 Jul;64(7):495-501.
doi: 10.1038/ja.2011.38. Epub 2011 May 18.

A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405

Yoko Fujita  1 , Masaaki Kizuka, Masanori Funabashi, Yasumasa Ogawa, Tomio Ishikawa, Koichi Nonaka, Toshio Takatsu
Affiliations

A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405

Yoko Fujita et al. J Antibiot (Tokyo). 2011 Jul.

Abstract

During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The structural elucidations were carried out by NMR and high-resolution mass spectral analyses, and they were classified as members of the liponucleoside antibiotics group with a sulfate group at the C-2' position. A-90289 A and B inhibited bacterial translocase I with IC(50) values of 36.5 ng ml(-1) and 33.8 ng ml(-1), respectively.

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